Abstract
Coronary heart disease (CHD) is one of the main causes of death worldwide. In the past few decades, several in-depth research on the pathological mechanisms and effective treatment methods for CHD have been conducted. At present, the intervention of a variety of therapeutic drugs and treatment technologies have greatly reduced the burden on global public health. However, severe arrhythmia and myocardial fibrosis accompanying CHD in the later stages need to be addressed urgently. Mitochondria are important structural components for energy production and the main sites for aerobic respiration in cells. Mitochondria are involved in arrhythmia, myocardial fibrosis, and acute CHD and play a crucial role in regulating myocardial ischemia/hypoxia. Mitochondrial dysfunction or mitophagy disorders (including receptor-dependent mitophagy and receptor-independent mitophagy) play an important role in the pathogenesis of CHD, especially mitophagy. Mitophagy acts as a “mediator” in the inflammatory damage of cardiomyocytes or vascular endothelial cells and can clear mitochondria or organelles damaged by inflammation under normal conditions. We reviewed experimental advances providing evidence that mitochondrial homeostasis or mitochondrial quality control are important in the pathological mechanism of CHD. Further, we reviewed and summarized relevant regulatory drugs that target mitochondrial function and quality control.
Highlights
Coronary atherosclerotic heart disease refers to the occurrence of atherosclerosis (AS) in the coronary artery, which narrows or blocks the coronary artery lumen or microvessels [1, 2]
Mitochondrial quality control can regulate the morphology and structure of mitochondria under the stimulation of hypoxia, ischemia, inflammation, and high glucose to respond to the physiological needs of cardiomyocytes and ensure the energy metabolism needs of cardiomyocytes under physiological or stress conditions
Upon disruption of the mitochondrial fusion/fission balance mechanism, mitophagy can remove mitochondria or organelles damaged by stress injury and maintain energy metabolism in cells
Summary
Reviewed by: Qi Feng, Tianjin Medical University General Hospital, China Jiasen Cui, Fudan University, China. In the past few decades, several in-depth research on the pathological mechanisms and effective treatment methods for CHD have been conducted. Severe arrhythmia and myocardial fibrosis accompanying CHD in the later stages need to be addressed urgently. Mitochondria are important structural components for energy production and the main sites for aerobic respiration in cells. Mitochondria are involved in arrhythmia, myocardial fibrosis, and acute CHD and play a crucial role in regulating myocardial ischemia/hypoxia. Mitochondrial dysfunction or mitophagy disorders (including receptor-dependent mitophagy and receptor-independent mitophagy) play an important role in the pathogenesis of CHD, especially mitophagy. We reviewed experimental advances providing evidence that mitochondrial homeostasis or mitochondrial quality control are important in the pathological mechanism of CHD. We reviewed and summarized relevant regulatory drugs that target mitochondrial function and quality control
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