Abstract
By selecting and inbreeding Wistar rats which are sensitive (S) or resistant (R) to the cataractogenic effect of galactose the S and R inbreed rat strains were created. Intense generation of oxygen radicals and enhanced lipid peroxidation were revealed in the liver and myocardium of the S rats. DNA rearrangements were found in the genome of S rats. Decreased oxidative phosphorilation and the lower respiratory control ratio were found in liver mitochondria of S rats. The formation of protein carbonyl groups and membrane fluidity were increased. SOD and catalase activity were decreased. Tumors, premature aging (low fecundity, growth retardation and short life-span), cataracts, cardiomyopathy-like changes in the myocardium, scoliosis are characteristics of the S rats. It was found that dysfunction of rat liver mitochondria is increased with age. Moreover, the increasing of mitochondria dysfunction is in good correlation with oxygen radical formation and oxidative damage of lipids and proteins. Thus, we suppose that mitochondria dysfunction plays an important role in the development of inherited predisposition to the enhancement of oxygen radical generation in the rats Wistar/S resulting in multipathological states.
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