Abstract
The aim: This study was designed to investigate the potential role of miRNA-155 in the pathogenesis of HPV-induced cervical cancer. Materials and methods: A total of 42 formalin-fixed paraffin-embedded (FFPE) cervical cancer tissue samples and 38 FFPE normal cervical tissue samples were used (they were collected at the Department of Pathology, Baghdad teaching hospital, Baghdad, Iraq, between January 2019 to January 2021). Following HPV testing and genotyping, the expression of miRNA-155 were evaluated by real-time PCR (qPCR). Results: A statistically significant up-regulation of miRNA-155 expression was observed in cervical cancer tissues compared to results in control group, regardless of HPV status and clinical grading. Conclusions: These data suggest that overexpression of miRNA-155 can delineate cervical cancer tissues from normal and may be a useful diagnostic biomarker for early detection of cervical cancer.
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