Abstract
Context: miRNAs can regulate the expression of genes by interfering in their mRNAs, acting as key regulators of diverse cellular activities. Osteoblast differentiation is an important process for skeletal developments and involves several mechanisms regulated by miRNAs. The data for this article was collected from recently published peer reviewed articles on role of miRNA in osteoblasts growth and differentiation. Evidence Acquisition: In this review, our understanding of bone remodeling has been highlighted along with the summarized role of different miRNA that regulate mesenchymal stem cell towards osteoblast differentiation for therapeutic purposes. Results: Treatments through miRNAs can prove to be beneficial due to its small size, easy synthesis, targeted and quick delivery. Conclusions: Further work is needed to be done to make miRNA treatments available to large number of people suffering from various bone diseases.
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