Abstract
Pancreatic cancer is a highly aggressive malignancy with metastatic potential and poor response to chemotherapy. Unfortunately, molecular-based targeted therapies failed to make significant progress against pancreatic cancer. One of the promising subjects of molecular oncology is the study of tumor microenvironment modulation for therapeutic purposes. In the present review, the description of pancreatic cancer microenvironment is provided, including intercellular interaction regulation which is important for tumor growth and progression. The study of this topic is important for the development of new therapies for pancreatic cancer.
Highlights
Tang Y., Xu X., Guo S., Zhang C., Tang Y., Tian Y., Ni B., Lu B., Wang H
An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma // PLoS One. 2014
One of the promising subjects of molecular oncology is the study of tumor microenvironment modulation for therapeutic purposes
Summary
Tang Y., Xu X., Guo S., Zhang C., Tang Y., Tian Y., Ni B., Lu B., Wang H. An increased abundance of tumor-infiltrating regulatory T cells is correlated with the progression and prognosis of pancreatic ductal adenocarcinoma // PLoS One. 2014. Vonlaufen A., Joshi S., Qu C., Phillips P.A., Xu Z., Parker N.R., Toi C.S., Pirola R.C., Wilson J.S., Goldstein D., Apte M.V. Pancreatic stellate cells: partners in crime with pancreatic cancer cells // Cancer Res. 2008. Tumour-derived exosomes and their roles in cancer // Zhong Nan Da XueXueBao Yi Xue Ban. 2010.
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