Abstract
Summary L-tryptophan was the best amino acid which increased the antibiotic yield. Addition of vitamins to the fermentation medium did not increase the antibiotic output, while addition of different concentrations of trace elements, such as Co(NO3)2, ZnCl2, (NH4)6Mo7 O24, and MnCl2 pushed the antibiotic yield to high titres. High concentrations of these trace elements decreased the antibiotic yield and directed the microbial activities towards biosynthesis of spiramycin II and III which are less toxic than spiramycin I. Maximum concentrations of Co(NO3)2, ZnCl2,(NH4)6Mo7O24, which supported the antibiotic yield, were 5 × 10−1, 5 × 10−3, 5 × 10−3, and 5 × 10−3, respectively.
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Schedule a callMore From: Zentralblatt fuer Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Zweite Naturwissenschaftliche Abteilung: Mikrobiologie der Landwirtschaft, der Technologie und des Umweltschutzes
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