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Abstract
With the aid of computational biology, we have studied the possibility of predicting the peptides able to evoke humoral immune response by using as experimental model the human HER-2/ neu breast cancer-associated antigen. We already demonstrated that HER-2/ neu peptides, that are the target of humoral human and mouse immune responses, correspond to those sequences having a low degree of sequence similarity to host’s proteome. Here we report that the linear peptide determinant of the anti-HER-2/ neu MAb-3 is characterized by a low degree of sequence similarity to mouse proteome in combination with high binding potential to specific MHC II molecule.
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