Abstract
The activation of hepatic stellate cells (HSCs) is a key event of hepatic fibrosis, and the polyamine metabolic pathway has been implicated to affects hepatic fibrosis. Methylthioadenosine phosphorylase (MTAP) the rate-limiting enzyme in the methionine and adenine salvage pathway catalyzes the phosphorylation of 5'-deoxy-5′-(methylthio)adenosine (MTA), which is a by-product of polyamine synthesis.
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