Abstract
Role of Metformin on Recurrent Miscarriage and Other Pregnancy Complications in Women with Polycystic Ovarian Syndrome
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age
Insulin resistance has been considered to be the main leading cause of miscarriage in PCOS women[8,9].It was hypothesized that hyperinsulinemic insulin resistance contributes to early pregnancy loss in the syndrome, and that decreasing hyperinsulinemic insulin resistance during pregnancy would reduce the rate of early pregnancy loss[10]
An insulin sensitizing agent, has been shown to have encouraging effects on several aspects of PCOS like insulin sensitivity, plasma glucose concentration & lipid profile [11].It is found that using Metformin during pregnancy in women with PCOS may reduce the pregnancy loss and reduce the risk of gestational diabetes & preterm labor [12]
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Results: Patients who continued to receive Metformin during pregnancy had better pregnancy outcome regarding early pregnancy loss and recurrent miscarriage, gestational diabetes development, IUGR & preterm labor.
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