Abstract
It has long been believed that there exists an intimate association between taste buds and gustatory nerve fibers during embryogenesis. The formation of taste buds is induced only after gustatory nerves innervate the embryonic epithelium. Furthermore, the integrity of taste buds also depends on a trophic influence of the gustatory nerves. It is well known that the taste bud disappears rapidly after denervation and reappears following regeneration of the nerve fibers. Still unclear, however, is how the gustatory nerves entering the tongue find the way to their appropriate target sites where the taste buds will develop. Farbman and Mbiene [1] suggested, in their study on the development of rat fungiform papillae, that the growth of sensory nerve fibers toward the gustatory epithelium needs the existence of a chemotrophic factor originating from the target epithelium.
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