Abstract
Mediatophore is a protein purified from Torpedo electric organ synaptosomes, which translocates acetylcholine (ACh) upon calcium action after reconstitution in artificial membranes. After expression in transfected cells, it endows these cells with a calcium-dependent release mechanism displaying clear quantal properties. The role of mediatophore in synaptic transmission is discussed in relation to the ultrastructural organization of the active zone and the cytosolic high calcium microdomains that transiently appear after presynaptic membrane depolarization.
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