Abstract
Background : Platelets are also known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. Increased MPV may be used as a marker of platelet activation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker. Methods : A retrospective study was conducted including 97 cases of leucocytosis with neutrophilia. 95 age and sex matched healthy individuals were used as controls. MPV values and total WBC counts were obtained on automated cell counter Horiba pentra ES60 and manual differential count was performed. Results : MPV did not show any significant change in the study group compared to the control group. MPV was noted to be higher in cases with associated thrombocytopenia, while MPV was lower in cases with thrombocytosis. Conclusion: MPV has no direct role in the evaluation of acute inflammation. However the increased MPV noted in cases of thrombocytopenia with neutrophilic leucocytosis suggests that activation of platelets causes a rise in MPV due to shape change and may be implicated in impending sepsis and disseminated intravascular coagulation due to the production of thromboxane A2 by activated platelets, warranting the need for further workup and prospective studies in order to establish the role of MPV as a marker for impending sepsis and DIC in cases with neutrophilic leucocytosis. DOI: 10.21276/APALM.1486
Highlights
Platelets are known for their role in the pathophysiology of vascular inflammation apart from their role in primary hemostasis and arterial thrombus formation
We aim to study the relationship of mean platelet volume with total white blood cell count in conditions resulting in neutrophilic leucocytosis and to assess if mean platelet volume may have any role as an inflammatory marker
The mean platelet volume in the 95 subjects with neutrophilic leucocytosis ranged from 6.5-11.5 μm3, with an average of 8.28 and SD of 1.02, while the MPV was 8.23 with SD of 0.8 and ranged from 6.8-10.6
Summary
Platelets are known for their role in the pathophysiology of vascular inflammation apart from their role in primary hemostasis and arterial thrombus formation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation via their stored cytokines and chemokines. MPV may be determined in the progenitor cell, the bone marrow megakaryocyte. Circulating platelets may, diminish in size during a normal circulating lifespan by shedding some of their surface components.[2] The platelet volume is found to be associated with cytokines (thrombopoietin, interleukin-6 and interleukin-3) that regulate megakaryocyte ploidy and platelet number and result in the production of larger platelets.[2,3,4] Increased MPV indicates increased platelet diameter, which can be used as a marker of production rate and platelet activation. Platelets are known for their role in the pathophysiology of vascular inflammation. Activated platelets can promote vascular inflammation, causing endothelial inflammation and subsequent leucocyte extravasation. We aim to study the relationship of MPV with total WBC count in cases with neutrophilic leucocytosis and to assess if MPV may have any role as an inflammatory marker
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