Abstract
Mechanical, physical, and functional properties of dental adhesives have been improved as a result of numerous investigations to achieve chemical balance between their hydrophilic and hydrophobic functional components. However degradation of the adhesive-dentin interface, with time, is a major limitation of contemporary simplified adhesive systems. Bond degradation occurs via water sorption, hydrolysis of ester linkages of methacrylate resins, and activation of endogenous dentin matrix metalloproteinases. This review discusses the role of Matrix Metalloproteinase Inhibitors and Collagen Cross Linkers in preserving the resin dentin bond.
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