Abstract
Background Burns are a global health problem, accounting for about 180 000 deaths annually especially in low- and middle-income countries. Many reports have concentrated on the role of platelet-rich plasma (PRP) in the treatment of soft tissue burn lesions. Aim This work aimed to study the role of Masson’s trichrome stain in evaluating the effect of PRP on induced thermal burn in adult male albino rats. Materials and methods In all, 50 adult male albino rats were divided into blood donor group (10 rats), control group (10 rats), and experimental group (30 rats). The experimental group was further subdivided into subgroups A, B, and C. For the experimental group, the rats were anesthetized and exposed to thermal burn. Subgroup A were subjected to contact thermal burn and left without treatment. Subgroup B were subcutaneously injected with 0.3 ml of autologous PRP. In subgroup C autologous topical PRP was applied. Skin specimens were obtained and stained by Masson’s trichrome for histological evaluation at days 1, 7, 14, and 28 after burn induction. Results The subgroups that were treated by PRP were found with better collagen organization and earlier restoration of normal histological features of skin tissue. Conclusion Application of different forms of PRP (injectable and topical) helps healing of burn wounds.
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