Abstract
Objectives. The expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a highly abundant and ubiquitously expressed long noncoding RNA (lncRNA), influences clinical parameters and may have prognostic value in cancer. This meta-analysis evaluated the prognostic role of MALAT1 in various cancers. Materials and Methods. Systematic literature searches of PubMed and EMBASE databases were conducted for eligible studies of the prognostic role of MALAT1 in cancer. Overall survival (OS), disease-specific survival (DSS), and disease-free survival (DFS) were analyzed. Summary hazard ratios (HRs) and 95% confidence intervals (95% CIs) were assessed to evaluate the influence of MALAT1 expression on patient prognosis. Results. Nine studies with a total of 932 patients were included in the analysis. Elevated MALAT1 expression was significantly correlated with poor OS (HR 2.02; 95% CI: 1.62–2.52; P < 0.001; I 2 = 0%). Subgroup analysis indicated that tumor type, histology type, ethnicity, and measurement technique did not affect the prognostic value of MALAT1 for OS. The HR of elevated MALAT1 for DFS was 2.78 (95% CI: 1.87–4.15; P < 0.001; I 2 = 0%). Conclusions. Elevated MALAT1 expression is correlated with poor OS in various types of cancer, suggesting that this gene is a prognostic factor for different types of cancer.
Highlights
Noncoding RNAs are RNAs that do not encode proteins and play important roles [1, 2]
We evaluated the impact of Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression on clinical prognosis by examining the hazard ratios (HRs) and corresponding 95% confidence intervals (95% confidence intervals (CIs))
The prognostic role of MALAT1 in cancer was evaluated by a meta-analysis of 9 studies including 932 participants
Summary
Noncoding RNAs (ncRNAs) are RNAs that do not encode proteins and play important roles [1, 2]. MALAT1 has since been associated with several human neoplasms, including lung [7, 8], liver [9], renal [10], colorectal [11], gastric [12], breast [13], cervical [14], pancreatic [15], and bladder cancers [16], uterine endometrial stromal sarcoma [17], glioma [18], and osteosarcoma [19] The expression of this gene may affect the clinical parameters and prognosis of cancer patients. We performed a systematic review and quantitative meta-analysis to assess the prognostic role of MALAT1 expression in various cancers
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