Abstract
The M2-type of pyruvate kinase (PKM2) is a key rate-limiting enzyme in glycolytic pathway,and is highly expressed in diverse tumor cells.In glycometabolism pathway of tumor,PKM2 can promote glycolysis and tumor cells growth through the mutual transformation between highly active tetramer and lowly active dimer.Tumor cells can regulate PKM2 expression and enzymatic activity through many mechanisms,such as transcription regulation,allosteric regulation and post-translational modification.PKM2 is expected to be a new target for oncotherapy because of its vital function in tumorigenesis and tumor metabolism. Key words: Pyruvate kinase ; Neoplasms ; Glycolysis; M2-type pyruvate kinase
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