Abstract
Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. However, the contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence. In the second part, we summarize some of the potential strategies targeting lysosomal proteins to enhance the therapeutic effect of MSCs.
Highlights
Mesenchymal stem cells (MSCs) are pluripotent stem cells with self-renewal (Pittenger et al, 1999), immunosuppressive (Bartholomew et al, 2002), and anti-inflammatory capabilities (Uccelli et al, 2008)
We focus on the relationship between lysosomal acidification and senescence
Lysosomes are involved in many other cellular processes, including nutrient sensing (Shin and Zoncu, 2020), metabolic signaling (Sancak et al, 2010), chromatin processing (Ivanov et al, 2013), and plasma membrane repair (Morgan et al, 2011). Each of these behaviors is influenced by the internal pH of the lysosome, which is maintained in the 4.5–5 pH range by the vacuolar H+-ATPases (V-ATPases) and the counterion transporter, which can be either a cation or an anion (Steinberg et al, 2010; Mindell, 2012)
Summary
Weijun Zhang 1,2†, Jinwu Bai 1,2†, Kai Hang 1,2, Jianxiang Xu 1,2, Chengwei Zhou 1,2, Lijun Li 1,2, Zhongxiang Wang 1,2, Yibo Wang 1,2, Kanbin Wang 1,2 and Deting Xue 1,2*. Reviewed by: Marisa Brini, University of Padua, Italy Tang Liu, Central South University, China. Stem Cell Research, a section of the journal Frontiers in Cell and Developmental. Mesenchymal stem cell (MSC) transplantation has been widely used as a potential treatment for a variety of diseases. The contradiction between the low survival rate of transplanted cells and the beneficial therapeutic effects has affected its clinical use. Lysosomes as organelles at the center of cellular recycling and metabolic signaling, play essential roles in MSC homeostasis. In the first part of this review, we summarize the role of lysosomal acidification dysfunction in MSC senescence.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
