Abstract
Abstract Therapeutic proteins can only be injected by parenteral routes, including intravenous (IV) and subcutaneous (SC) injection. It is highly desirable for therapeutic proteins to be self‐administered SC, than by IV injection, by patient themselves, thus providing convenience for patients, and improving the quality of life and treatment adherence. Bioavailability of protein drugs after SC administration is quite variable ranging from 20% to 95%. One possible source of the variation in the bioavailability of protein drugs is the difference in presystemic catabolism of proteins in the interstitial space and/or during the transport in lymphatic vessels after SC administration. This chapter provides an overview of current knowledge of the processes of protein absorption after SC administration. In addition, the underlying mechanisms that govern the SC absorption as well as the factors that influence the SC absorption will also be discussed.
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