Abstract
Deregulation of long non-coding RNAs (lncRNAs) is emerging as a common feature of human tumors, suggesting that their investigation may uncover novel oncogenic mechanisms. Previous studies suggested that the alteration of some lncRNAs might play an important role in multiple myeloma (MM); however, the complete expression landscape of lncRNAs has not been elucidated. In the present work we characterized the lncRNAs transcriptome of MM determining their potential involvement in this disease. Firstly, we performed paired-end strand-specific RNA-seq (ssRNA-seq) in 38 purified plasma cell (PC) samples from MM patients, 3 bone marrow PCs (BMPCs) of healthy donors, and in distinct normal B-cell populations (Naïve, Centroblasts, Centrocytes, Memory and Tonsilar PCs).
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