Abstract
Publisher Summary This chapter discusses the nature of lipid rafts and their role in the assembly and budding of some viruses. Lipid rafts containing sphingolipid-cholesterol clusters in the liquid-ordered phase are TritonX-100-insoluble at low temperature. They are dynamic in nature, vary in size, and are dispersed in the plasma membrane and trans-golgi network. They are involved in various cell functions, including clathrin-independent endocytosis, transcytosis, membrane trafficking, and membrane signaling required for many biological functions. These lipid rafts along with other host components play an important role and actively participate in the assembly and budding of many enveloped viruses, particularly for viruses budding from the plasma membrane. They provide multiple functions in the budding process. They are involved in transporting and targeting viral components to the assembly site and aid in concentrating viral components at the budding site, thereby facilitating their interaction and functioning as a platform for budding of these viruses.
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