Abstract
Abstract The effect of roxatidine, a histamine H 2 -receptor antagonist, on acute gastric mucosal injury induced by aspirin-HCl was investigated from the standpoint of lipid peroxidation and neutrophil accumulation in rats. Acute mucosal injury was produced on the rat stomach by intragastric administration of aspirin and HCl. Pretreatment with roxatidine at doses of 3 and 10 mg/kg significantly reduced the lesion area induced by aspirin-HCl. The increase in lipid peroxides in the gastric mucosa 3 h after aspirin-HCl treatment was significantly inhibited by roxatidine, and the concentration of lipid peroxides closely paralleled the increase in total area of erosions. Tissue-associated myeloperoxidase (MPO) activity, an index of neutrophil accumulation, in the gastric mucosa increased significantly 3 h after aspirin-HCl administration, and the increase in MPO activity was significantly inhibited by roxatidine and paralleled the increase in total area of erosions. An in vitro study demonstrated that roxatidine scavenged hydroxyl radicals, inhibited superoxide production from activated neutrophils, and inhibited lipid peroxidation of the rat gastric mucosal homogenates. These results indicate that the protective effect of roxatidine against gastric injury induced by aspirin-HCl may result, in part, from its antioxidative properties.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
