Abstract
Endotoxemia remains a critical clinical dilemma due to high mortality rate provoked by the systemic inflammatory response, which often leads to sever hepatic injury and immune dysregulation. This study aimed at delineating the modulatory effect of fucoxanthin (FX) and γ-radiation (IR) on LPS-induced spleen and liver injury. LPS sensitized mice showed enhanced splenic and hepatic TLR4/NF-κB- signaling, suppressed splenic α-7nAchR-expression, activated hepatic RIPK/HMGB-1, impaired hepatic leptin/STAT-3 signaling, extensive oxidative stress, and marked apoptosis with sever degenerative histopathological examination. FX and/or IR protected liver and spleen against detrimental effects evoked by LPS. Overall, FX and/or IR exhibited protective effect against endotoxemia.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.