Abstract
Probiotics, prebiotics, and synbiotics are potential mediators to maintaining healthy intestinal flora and have garnered an area of wide research in the past few years. The current study assesses the in vivo effects of probiotic (Lactobacillus plantarum MBTU-HK1), prebiotic (acacia gum) (either singly or in combination as a synbiotic on growth performance), biochemical, hematological, physiological, and immunological effects and their role in the reduction of procarcinogen enzyme activities in male Balb/c mice. The absence of treatment-related toxicity and a normal physiological range of biochemical and hematological parameters ensure their safe consumption. The synbiotic group was found to possess lowered cholesterol levels and enhanced protein and mineral content. The probiotic and synbiotic groups reinforced immunoglobulin levels and had a modulatory effect on phagocytosis. A lymphocyte proliferation pattern suggested the stimulatory effect of synbiotic combination on splenocyte viability and proliferation. Total antioxidant capability in the liver was determined by a 2,2-diphenyl-1-picrylhydrazyl assay and all the treatment groups were found to possess increased scavenging activity. Synbiotic and prebiotic treatment was observed to lead to reduced tumor necrosis factor α (TNF-α) levels. Bacterial procarcinogenic fecal enzyme activities were found to be decreased, proving their role in the prevention of colon cancer incidence. This study proves the potency and safety of oral administration of L. plantarum MBTU-HK1 and acacia gum either individually or in combination.
Highlights
“Let food be thy medicine and medicine be thy food”, as stated by Hippocrates, is the thought of today’s health-aware population
Lactobacillus plantarum is generally used as a probiotic and is “generally recognized as safe” (GRAS), has a qualified presumption of safety (QPS) status, has a high ability to survive in the gastrointestinal tract (GI) and adhere to its epithelial cells, and most importantly is a safe strain (Food and Agriculture Organization and World Health Organization) for animals and humans [4]
Results of the current study indicated that there was no adverse effect on the general health status of the mice belonging to both the treatment and control groups with the oral administration of probiotics (L. plantarum MBTU-HK1), synbiotics (L. plantarum MBTU-HK1 and acacia gum) and prebiotics
Summary
“Let food be thy medicine and medicine be thy food”, as stated by Hippocrates, is the thought of today’s health-aware population. Lactobacillus plantarum is generally used as a probiotic and is “generally recognized as safe” (GRAS), has a qualified presumption of safety (QPS) status, has a high ability to survive in the gastrointestinal tract (GI) and adhere to its epithelial cells, and most importantly is a safe strain (Food and Agriculture Organization and World Health Organization) for animals and humans [4]. The identification of a prebiotic that confers synergistic effects with a probiotic is, of great commercial value [5]. Synbiotics, and prebiotics for the treated groups had no adverse effects oTnhtehree wmaisceno(ncohamnogretainlitgye,naebrnalohrmeaaltlhaacptipveiatyr,anchceanbgetewienenfotohde atrnedatmweantetrainndtackoentororlsgyrmoupptos.ms. Synbiotics, and prebiotics for the treated groups had no adverse effects on the mice
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
