Role of Intravenous Hyoscine Butylbromide Injection on the Duration and Progress of First Stage of Labour in Primigavidae

Abstract

Background: Labour is a physiologic process that results in expulsion of the products of conception outside the uterus throughout 3 stages. It is achieved with changes in the biochemical connective tissue and with gradual effacement and dilatation of the uterine cervix as a result of rhythmic uterine contractions of sufficient frequency, intensity, and duration. Hyoscine butylbromide (HBB) belongs to the parasympatholytic group of drugs and is a semisynthetic derivative of scopolamine. It is a quaternary ammonium derivative, which exerts a spasmolytic action on the smooth muscle of the gastrointestinal, biliary, and genitourinary tracts. Methods: A case control study conducted on 150 women coming to Al Azhar University Maternity Hospital.Patients who meet the inclusion criteria were asked to participate in the study and a verbal consent was obtained from each patient. Patients were divided into three equal groups (A, B, C). A single dose of the drug (placebo or HBB 20mg or HBB 40 mg) was injected intravenously slowly to groups A, B, C respectively. Labouring mothers were monitored in bed. Vaginal examination was conducted every two hours. The duration of the first stage was calculated from the time of cervical dilatation of three to four centimeters in active labour until a fully dilated cervix was observed Results: showed significant difference between the three groups regarding the progress of labour. There was a significant decrease in the duration of the active phase of first stage of labour in study groups who received hyoscine butylbromide compared to placebo group. The decrease in the duration of active phase of first stage of labour was not related to the drug dose. There was no significant difference between the three groups regarding the second stage duration. There were no significant adverse effects of hyoscine butylbromide on either mothers or neonates. Conclusion: Hyoscine butylbromide helps to decrease the duration of active phase of labour in primigravdae with no side effects on either the mother or the neonate. This decrease is not related to the dose of the drug. Hyoscine butylbromide (HBB) belongs to the parasympatholytic group of drugs and is a semisynthetic derivative of scopolamine. It is a quaternary ammoniu m derivative, which exerts a spasmolytic action on the smooth muscle of the gastrointestinal, biliary, and genitourinary tracts. Role of intravenous hyoscine butylbromide injection on the duration and progress of first stage of labour in primigavidae