Abstract
sBackgroundPrognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. But the role of intraparotid nodes (IPNs) remains unclear, therefore, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC.MethodsOne hundred and ninety patients were included for analysis finally. Data regarding demography, pathological characteristics, IPN metastasis, TNM stage, follow up was collected and evaluated. The recurrence-free survival (RFS) was the main study endpoint.ResultsA total of 47 (24.7%) patients had IPN metastasis, and the IPN metastasis was significantly related to tumor stage, pathologic N stage, lymph-vascular invasion, perineural invasion, and disease grade. Recurrence occurred in 34 (17.9%) patients. For patients without IPN metastasis, the 10-year RFS rate was 88%, for patients with IPN metastasis, the 10-year RFS rate was 54%, the difference was significant (p < 0.001). Further Cox model analysis confirmed the independence of IPN metastasis in predicting the prognosis.ConclusionThe IPN metastasis is relatively common in parotid MEC, it is significantly related to tumor stage and disease grade, IPN metastasis means worse recurrence-free survival.
Highlights
Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion
Parotid gland cancer is an uncommon neoplasm [1], but according to their architectural and cytological features, there were 24 types of malignant tumors classified by The World Health Organization [2, 3], mucoepidermoid carcinoma (MEC) is the most common pathologic subtype, some clinic-pathologic variables, including histologic grade, lymphovascular and perineural invasion as well as tumor stage, have been well described to be associated with the prognosis in parotid MEC [4,5,6]
Lymph nodes existed in both lobes of the parotid gland, undiagnosed metastatic intraparotid node (IPN) might be caused by non-total parotidectomy, and recurrent
Summary
Prognostic factors for parotid mucoepidermoid carcinoma (MEC) usually include disease grade, tumor stage, node stage, perineural invasion, and lymphovascular invasion. The role of intraparotid nodes (IPNs) remains unclear, the study aimed to analyze the significance of IPNs in predicting recurrence in parotid MEC. Because of the exceptional growth process, there are intraparotid nodes (IPNs) in the parotid gland [7], its prognostic value remains unclear [8,9,10,11]. The IPNs are classified into superficial and deep lobe nodes [12], the current study aimed to evaluate the IPN metastasis rate and the significance of IPN metastasis in predicting recurrence in parotid MEC
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