Role of intestinal microbiota in development of atopic dermatitis and methods of its treatment in case of its violation

Abstract

Representatives of the normal microflora of intestinal biota perform a physiologically important function of maintaining the constancy of the internal environment of the body, take part in the formation of the immunobiological reactivity of the macroorganism. Violation of normocenosis contributes to the chronicity of pathological processes (in particular, atopic dermatitis).Material and methods.Under supervision were 36 patients with atopic dermatitis. Before treatment, 86.1 % of patients had persistent or intermittent clinical symptoms of dysbiosis. Depending on the treatment, patients were divided into 2 groups: group 1 (n = 19) received an external preparation with zinc pyrithione (Cinokap® cream / spray depending on the prevailing clinical picture), specialized dermatocosmetics. In addition to topical therapy, patients of group 2 (n = 17) received Lactofiltrum® 2 tablets 3 times a day for 14 days.Results.After 4 weeks, the total index of the DIHS index decreased in the 1st group by 78.8 %, in the 2nd group by 85.8 %, BRS decreased in the 1st group by 89.2 %, in the 2nd group by 97.1 %. By the end of the course of therapy, DIC improved by 62.4 and 84.1 %, respectively.Conclusions.The inclusion of the drug Lactofiltrum® in the treatment complex leads to a more rapid and pronounced regression of skin rashes and subjective sensations, normalization of the gastrointestinal tract, which contributes to a significant improvement in the quality of life. The drug has a favorable safety profile, convenient to use.