Abstract
The aim of the review is to show possible links between intestinal microbiota and colorectal carcinogenesis, to describe the procarcinogenic properties of microorganisms associated with the development or proliferation of colorectal cancer. The gut microbiota plays a leading role in metabolism, providing important metabolites to the macroorganism. In humans, there is a spatial variability in the qualitative and quantitative microbiota composition. The intestinal microbiota provides the colony resistance, protecting it from colonization by opportunistic and pathogenic microorganisms. There is more and more data on the role of the gut microbiota in the development of colorectal cancer. The profound study of the gut microbiome in various populations is required, which will allow to identify other microorganisms associated with the development or proliferation of colorectal cancer. It can be used as biomarkers for colorectal cancer screening and predicting the response to immunotherapy.
Highlights
describe the pro-carcinogenic properties of microorganisms associated with the development or proliferation of colorectal cancer
identify other microorganisms associated with the development or proliferation of colorectal cancer
It can be used as biomarkers for colorectal cancer screening
Summary
The aim of the review is to show possible links between intestinal microbiota and colorectal carcinogenesis, to describe the pro-carcinogenic properties of microorganisms associated with the development or proliferation of colorectal cancer. For citation: Sukhina M.A., Lyagina I.A., Safin A.L., Frolov S.A., Kashnikov V.N. Role of intestinal microbiota in colorectal carcinogenesis (review). У пациентов с КРР на более ранней стадии наблюдалось увеличение Proteobacteria и Fusobacteria и уменьшение Bacteroides в нормальной слизистой оболочке по сравнению со здоровыми людьми [9].
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