Role of intestinal microbiocenosis in pathogenesis of acute myocardial infarction

Abstract

Objective. To study changes in the qualitative and quantitative composition of the microbiome of the gastrointestinal tract as one of the main factors affecting the state of general and local immunity in patients with acute myocardial infarction.Methods. According to the recommendations of the European Society of Cardiology 2019, the cardiological status of the subjects was established. Based on the methodology proposed by the Moscow Research Institute of Epidemiology and Microbiology n. a. G. N. Gabrichevsky, the qualitative and quantitative composition of the intestinal microbiota was determined, followed by an assessment of the degree of microbiological disorders according to the industry standard ‘Protocol of patient management. Intestinal dysbiosis’.Results and conclusions. A bacteriological study revealed a reduction in the main representatives of the normobiota: Bifidobacterium, Eubacterium, Lactobacterium, Enterococcus spp., forming the ‘metabolic core’ of intestinal microbiocenosis. The results obtained are part of a clinical and laboratory study of changes in the microbiota of the body in diseases of the circulatory system and can serve as a basis for developing recommendations for effective treatment and prevention of cardiovascular pathology, taking into account the state of intestinal microbiocenosis.