Role of Interleukin-8 with Special Progress of Atopic Dermatitis

Abstract

Atopic dermatitis (AD) is a recurrent pruritic chronic inflammatory skin disease, also known as atopic eczema and neurodermatitis sown. Its actual cause is still unknown, but association of disease progression may be related to immune system abnormalities. Many studies reported that AD lesions are linked with mainly increased no. of T lymphocytes with other inflammatory cells including monocytes, eosinophils and macrophages. T Lymphpocytes mediate inflammation and local immune response by secondary antibody production which are involved in cell-mediated immunity and delayed type hypersensitivity inflammatory reactions. IL-8 which is a proinflammatory cytokine and have high chemotactic activity on neutrophils, T lymphocytes and basophils along with activation of proinflammatory cells to perform immune functions. High expression of IL-8 was also reported in AD lesions which can cause chemotaxis, aggregation and activation of inflammatory cells. It also promotes IL-4 and IL-3 overexpression resulting in the proliferation and differentiation of mast cells which further aggravates AD. Here, in this manuscript IL-8 and related cytokines involved in atopic dermatitis pathogenesis and progression are reviewed more than spring season in dogs.