Role of Interleukin-4, Interleukin-10, and Tumor Necrosis Factor-α Polymorphic Genes in the Pathogenesis of Occupational Allergic Dermatoses.

Abstract

Study of polymorphic genes of pro- and anti-inflammatory cytokines (IL-4, IL-10, TNF-α) in patients with occupational allergic dermatoses showed significantly higher frequency of polymorphic variants of cytokine genes IL4 C589T, IL10 C819T, IL10 G1082A, IL10 C592A, and TNF G308A in comparison with the population control. The presence of homozygous variant IL10 G1082A--AA in 80% cases characterizes early disease development, i.e. within 3 years after the first exposure to the occupational factor.