Abstract
Role of interferon-induced GTPases in leishmaniasis.
Highlights
FORMAL COMMENTOPEN ACCESS Citation: Lipoldova M, Sohrabi Y (2022) Role of interferon-induced GTPases in leishmaniasis
Infection of bone marrow–derived macrophages from BALB/c mice with Leishmania major promastigotes led to up-regulation of expression of Gbp2b/Gbp1, Gbp2, Gbp3, Gbp6, and Gbp7 mRNA [10]
Monitoring mouse embryonic fibroblasts (MEFs) and A549 cells revealed that mouse guanylate-binding proteins (GBPs) and human GBP1 do not efficiently target Leishmania-containing vacuoles (LCVs) in MEFs and A549 cells, respectively, but facilitate the recruitment of lysosomal markers like lysosome-associated membrane proteins (LAMPs) and the autophagosome marker light chain 3 (LC3) to the LCVs
Summary
OPEN ACCESS Citation: Lipoldova M, Sohrabi Y (2022) Role of interferon-induced GTPases in leishmaniasis. RAecUen:t PstluedaiseescheacvkewshedthleirgthhteoednitshteotrhoeleseonfteinntceerRfeercoenntstudiesha (IAFNU)-:inPdleuacsiebnleotGetThPaattsheesaabsbrreegvuialattiornsIFofNihmamsbueneintiyntoroidnufeccetdiofonr.inFtaerrifaesrAonminotrhiemseanntednccoelR- ecentstudiesha leagues [1] describe differences in the transcriptome of blood cells isolated from patients infected with Leishmania braziliensis and healthy controls They highlighted IFNγ and cytolytic transcriptional signatures characteristic for this cutaneous leishmaniasis. Extensive analyses of host– pathogen interactions revealed multiple molecular effectors mediating effects of IFNγ on pathogens by direct killing, production of killing molecules, or limiting pathogen growth [7] Some of these molecular effectors such as NADPH oxidase (Phox), nitric oxide synthase (NOS2), indoleamine 2,3-dioxygenase (IDO) [8], and natural resistance–associated macrophage protein 1/solute carrier family 11 member 1 (NRAMP1/SLC11A1) [9] have been shown to participate in defense against Leishmania parasites. Response mediated by GBPs depend on the cell type? And lastly, does the antimicrobial defense mediated by GBPs depend on the stage of the disease?
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