Role of insulin-like growth factor 1, sex and corticosteroid hormones in male major depressive disorder

Hiroshi Arinami,Toshiyuki Someya,Nobuto Tsuneyama,Misuzu Tajiri,Yutaro Suzuki

doi:10.1186/s12888-021-03116-2

Hiroshi Arinami, Toshiyuki Someya + Show 3 more

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https://doi.org/10.1186/s12888-021-03116-2

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Journal: BMC Psychiatry	Publication Date: Mar 17, 2021
Citations: 6	License type: open-access

Affiliation: Niigata University

Abstract

BackgroundHormones of the hypothalamic–pituitary–gonadal (HPG), hypothalamic–pituitary–adrenal (HPA), and hypothalamic–pituitary–somatotropic (HPS) axes are potentially involved in major depressive disorder (MDD), but these hormones have not been simultaneously investigated in male patients with MDD. We investigated the association between male MDD symptoms and estradiol, testosterone, cortisol, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF1).MethodsSerum estradiol, testosterone, cortisol, DHEAS, and IGF1 levels were measured in 54 male patients with MDD and 37 male controls and were compared with clinical factors. We investigated the associations between hormone levels and Hamilton Depression Rating Scale (HAM-D) scores. The correlations among hormones were also investigated.ResultsPatients had significantly lower estradiol levels than controls (22.4 ± 8.4 pg/mL vs. 26.1 ± 8.5 pg/mL, P = 0.040). Serum estradiol levels were negatively correlated with HAM-D scores (P = 0.000094) and positively correlated with Global Assessment of Functioning scores (P = 0.000299). IGF1 levels and the cortisol:DHEAS ratio were higher in patients than in controls (IGF1: 171.5 ± 61.8 ng/mL vs. 144.1 ± 39.2 ng/mL, P = 0.011; cortisol:DHEAS ratio: 0.07 ± 0.05 vs. 0.04 ± 0.02, P = 0.001). DHEAS levels were lower in patients than in controls (227.9 ± 108.4 μg/dL vs. 307.4 ± 131.2 μg/dL, P = 0.002). IGF1, cortisol:DHEAS ratio, and DHEAS were not significantly correlated with HAM-D scores. Cortisol and testosterone levels were not significantly different between patients and controls. Serum estradiol levels were positively correlated with DHEAS levels (P = 0.00062) in patients, but were not significantly correlated with DHEAS levels in controls.ConclusionEstradiol may affect the pathogenesis and severity of patients with MDD in men, and other hormones, such as those in the HPA and HPS axes, may also be involved in male MDD. Additionally, a correlation between estradiol and DHEAS may affect the pathology of MDD in men.

Highlights

The incidence of major depressive disorder (MDD) differs by sex [1]; the pathogenesis of MDD is likely to be affected by sex hormones of the hypothalamic–pituitary–gonadal (HPG) axis
Serum estradiol levels and serum DHEA S levels were lower in the MDD group than in the control group (Table 2)
No significant differences in serum cortisol levels and serum testosterone levels were found between the MDD group and control group (Table 2)

Summary

Introduction

The incidence of major depressive disorder (MDD) differs by sex [1]; the pathogenesis of MDD is likely to be affected by sex hormones of the hypothalamic–pituitary–gonadal (HPG) axis. Few studies have investigated the relationship between symptom severity in male patients with MDD and estradiol, including testosterone. In patients with MDD, increased cortisol and decreased dehydroepiandrosterone sulfate (DHEAS) have been reported [7,8,9,10,11]. Hormones of the hypothalamic–pituitary–gonadal (HPG), hypothalamic–pituitary–adrenal (HPA), and hypothalamic–pituitary–somatotropic (HPS) axes are potentially involved in major depressive disorder (MDD), but these hormones have not been simultaneously investigated in male patients with MDD. We investigated the association between male MDD symptoms and estradiol, testosterone, cortisol, dehydroepiandrosterone sulfate (DHEAS), and insulin-like growth factor 1 (IGF1)

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