Abstract
RATIONALE: One characteristic feature of bronchial asthma is airway inflammation elicited by inflammatory cells such as T cells and eosinophils. The chronic inflammation leads to epithelial remodeling which is an important mechanism of irreversible airway obstruction. Insulin-like growth factor (IGF)-I acts on fibroblasts as a progression factor to push cells toward proliferation and activation to synthesize collagen. Although PDGF is involved in remodeling of asthma, the role of IGF-I is unclear so far.
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