Abstract

Type 1 diabetes mellitus (T1DM) is a complex autoimmune disease resulting from the specific destruction of islet β cells by T cells and B cells.The pathogenesis of T1DM remains elusive.Ultimately,the interplay between natural immune cells and specific immune cells triggers the destruction of β cells and onset of T1DM.The interaction of macrophage,natural kill cell,natural killer T cells and dendritic cells induced by susceptible gene and environmental factors with antigen-specific lymphocytes has been implicated in the development of autoimmune diabetes in animal models and patients with T1DM.Studies of the role of natural immune cells in initiating T1DM may provide innovative clinical approaches for prevention or treatment of T1DM. Key words: Type 1 diabetes mellitus; Innate autoimmune cells ; Autoimmune

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