Abstract
Role of Impaired Oxalate Homeostasis in Cardiovascular Disease in Patients With End-Stage Renal Disease: An Opinion Article.
Highlights
Oxalate is an ionic form of a potentially toxic oxalic acid that is formed in the human body from a combination of food sources and their absorption in the gastrointestinal tract, as well as the endogenous synthesis of glyoxylate (40%) and ascorbic acid (30%) (Jonassen et al, 2005; Robijn et al, 2011)
The accumulation of oxalate may be associated with oxidative stress, inflammation (Khan, 2014; Ermer et al, 2016; Dominguez-Gutierrez et al, 2018; Korol et al, 2021) and a high risk of cardiovascular disease (CVD) (Liu et al, 2014; Fan X et al, 2017; Arafa et al, 2020; Demikhov et al, 2020) in patients with kidney stones
Impaired oxalate homeostasis is a well-known occurrence in patients with end-stage renal disease (ESRD), a high plasma oxalic acid (POx) concentration has never been considered a trigger for oxidative stress, systemic inflammation, and CVD risk in these patients
Summary
State Institution “Institute of Nephrology National Academy of Medical Science of Ukraine”, Kyiv, Ukraine. Edited by: Norberto Perico, Istituto di Ricerche Farmacologiche Mario Negri (IRCCS), Italy. Oxalate Homeostasis in Cardiovascular Disease in Patients With End-Stage Renal Disease: An
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