Abstract
T helper 17 cell (Th17) producing interleukin-17 (IL-17) is involved in immune response of tuberculosis, and participates in the immunoregulation of tuberculosis with Th1. IL-17 provides the protective immunity against infection of Mycobacterium tuberculosis. It can control the infection of Mycobacterium tuberculosis by promoting the production and recruitment of neutrophil, enhancing the protective response of interferon-γ,and promoting the formation of granuloma. However,the overexpression of IL-17 would cause damage to the body. The immune pathological changes are extensive and severe tissue damage mainly mediated by neutrophil cells. Interferon-γ has negative regulation on IL-17 to suppress tissue damage caused by the overexpression of IL-17. Therefore, the regulation of Thl and Th17 responses is critical to control bacterial growth and prevent immune pathological lesion in the chronic infection of tuberculosis. Key words: Interleukin-17; T helper 17 cell; Tuberculosis; Immune response
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