Role of IL-8 as macrophage activation and C-reactive protein in disease prognosis of coronavirus disease-2019 patients

Abstract

Coronavirus disease 2019 (COVID 19) may cause multi-organ involvement due to viral-induced hyper inflammation. In coronavirus disease‐2019 (COVID19) cases, hyper inflammation is associated with the severity of the disease[1]. High levels of circulating cytokines were reported in severe COVID-19 patients[2, 3]. Illness prognosis and severity are predicted by interleukin-8 (IL-8) in COVID-19 patients, as well as its function as a powerful chemo attractant and activator of monocytes, lymphocytes, and neutrophils, which may attract neutrophils to infected regions and has been linked to tissue damage[4, 5]. C-reactive protein (CRP) has been identified as an essential marker that changes dramatically in severe COVID-19 patients. CRP is a liver protein that acts as an early indicator of infection and inflammation. [6]