Abstract
The aim of this study was to assess the relationship between IL-18 gene polymorphisms and HBV-related diseases and whether these polymorphisms influence its expression in the Guangxi Zhuang population. We enrolled 129 chronic HBV infected (CHB) patients, 86 HBV-related liver cirrhosis (LC) patients and 160 healthy controls in our study. Polymerase chain reaction-restriction fragment length polymorphism methods were used to detect IL-18 gene -607C/A, -137G/C polymorphisms, and an ELISA kit was employed to determine serum IL-18 levels. No correlation was found between the -607C/A polymorphism and risk of HBV-related disease. For the -137G/C polymorphism, the GC genotype and C allele were associated with a significantly lower risk of CHB (95%CI: 0.32-0.95, p=0.034 and 95%CI: 0.35-0.91, p=0.018) and HBV-related LC (95%CI: 0.24-0.89, p=0.022 and 95%CI: 0.28-0.90, p=0.021). A similar decreased risk was also found with the A-607C-137 haplotype. With respect to IL-18 expression, it was significantly lower in both patient groups, but no association was noted between the two polymorphisms in the IL-18 gene and its expression. Our study indicated that the -137C allele in the IL-18 gene may be a protective factor for HBV-related disease, and serum IL-18 level may be inversely associated with CHB and HBV-related LC.
Highlights
Highly effective vaccines against hepatitis B virus (HBV) have been available since 1982, HBV infection remains the tenth leading cause of death worldwide, accounting for 500 thousand to 1.2 million deaths annually (Lavanchy, 2004)
The aim of this study was to assess the relationship between IL-18 gene polymorphisms and HBV-related diseases and whether these polymorphisms influence its expression in the Guangxi Zhuang population
With respect to IL-18 expression, it was significantly lower in both patient groups, but no association was noted between the two polymorphisms in the IL-18 gene and its expression
Summary
Highly effective vaccines against hepatitis B virus (HBV) have been available since 1982, HBV infection remains the tenth leading cause of death worldwide, accounting for 500 thousand to 1.2 million deaths annually (Lavanchy, 2004). Asian Pacific Journal of Cancer Prevention, Vol 16, 2015 6019 the promoter region has demonstrated that a change from hepatitis B surface antigen (HBsAg) and visited the allele C to A at 607 disrupts the cAMP-responsive element- outpatient clinic of the Gastroenterology Department at the binding protein binding site, and that a change from allele First Affiliated Hospital of Guangxi Medical University G to C at 137 interrupts the H4TF-1 nuclear factor binding (Guangxi, China) between May and December 2013, site Changes in these sites have resulted in were recruited into this study. Clinical research has revealed a correlation levels >1,000 copies/mL; and iv) without any other type between these two SNPs and an individual’s risk of HBV of liver disease such as chronic hepatitis C or alcoholic infection. Sciences (SPSS, version 16.0) and statistical significance75.0 was set at a two side P value of 0.05
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