Abstract
Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation. However, the involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure. This retrospective observational study included 150 patients with primary RRD (macula-on, n = 63; macula-off, n = 87) who underwent 25-gauge microincision vitrectomy surgery (25G MIVS). Total retinal blood flow was represented by the mean blur rate (MBR) of the optic nerve head vessel, measured by laser speckle flowgraphy preoperatively and until 6 months postoperatively. Aqueous humor samples were obtained during surgery to determine cytokine concentrations by enzyme-linked immunosorbent assay. At 3 and 6 months postoperatively, there were no significant differences between eyes with macula-on RRD and fellow eyes. However, in macula-off RRD, MBR remained significantly lower in RRD eyes 6 months postoperatively (P < 0.05). Log-transformed levels of soluble intercellular adhesion molecule-1 (sICAM-1) were negatively correlated with relative MBR (r-MBR, RRD eye/fellow eye) before surgery (r = − 0.47, P = 0.01) in macula-on, but not macula-off, RRD. Six months postoperatively, r-MBR correlated significantly with sICAM-1 levels (r = − 0.36, P = 0.02) in macula-off RRD. ICAM-1 may play a role in RRD-induced deterioration of retinal circulation.
Highlights
Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation
Using laser speckle flowgraphy (LSFG), Iwase et al examined the longitudinal changes in retinal circulation measured before and after 25-gauge (25G) microincision vitrectomy surgery (MIVS) or scleral buckling in RRD eyes with the macula still attached[4]
Time courses of best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP), mean arterial pressure (MAP) and Ocular perfusion pressure (OPP) are shown in Fig. 1A–E, respectively
Summary
Many studies have demonstrated that rhegmatogenous retinal detachment (RRD) leads to impaired retinal circulation. The involvement of inflammation in the RRD-induced worsening of retinal circulation was obscure This retrospective observational study included 150 patients with primary RRD (macula-on, n = 63; macula-off, n = 87) who underwent 25-gauge microincision vitrectomy surgery (25G MIVS). Using LSFG, Iwase et al examined the longitudinal changes in retinal circulation measured before and after 25-gauge (25G) MIVS or scleral buckling in RRD eyes with the macula still attached (macula-on RRD)[4]. They demonstrated that 25G MIVS, but not scleral buckling, resulted in the recovery of retinal circulation by 6 months postoperatively[4]. Using LSFG, we compared the longitudinal changes in retinal circulation after macula-on and macula-off RRD treated with 25G MIVS
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