Abstract
This study examines the possible functional role of two hyperpolarization-activated conductances in the interaural intensity difference detector lateral superior olive (LSO). Inputs of these neurons are transformed into an output, which provides a firing-rate code for a certain interaural intensity difference range. The I h conductance's effect is partly masked by the inwardly rectifying outward K + current's effect. Since resting potential, input resistance, membrane time constant, as well as synaptic release probability are all affected by the pharmacological agents used in vitro experiments, it is not easy to dissect out the role of these conductances. We therefore used computer simulations to investigate this issue. The interplay between the two hyperpolarization-activated conductances, first-spike latency, f-I function, input resistance and the width of the dynamic firing regime were examined.
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