Abstract
Rifampicin, a specific inhibitor of RNA synthesis in bacteria, markedly inhibits growth of λ phage on wild-type Escherichia coli. Synthesis of both early and late λ messenger RNA was inhibited by rifampicin even when the drug was added after phage messenger RNA synthesis already started. In contrast, normal phage growth was observed on any of the rifampicin-resistant mutants tested producing RNA polymerase that are themselves resistant to the drug. These results suggest that host RNA polymerase (at least components relating to rifampicin sensitivity) is involved in expression of λ genes throughout the phage development.
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