Abstract
Histone acetylation is a crucial part histone modifications in epigenetics.Histone acetylation is involved in the onset diabetes and diabetic complications,through the mechanism inducing hyperglycemia by means of metabolic memory effect,interfering islet development and regulating the expression inflammatory factors and pathogenic genes.Genome-wide association studies are gradually unveilling the pathogenesis diabetes and preclinical studies are rapidly elucidating that histone deacetylase should be considered as a new target for the treatment diabetes. Key words: Diabetes mellitus; Histone acetylation; Metabolic memory; Genome wide association studies
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