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Abstract
High levels of histamine and of its synthetizing enzyme, histidine decarboxylase, are found in growing experimental tumors. Jacques Bartholeyns and John Fozard describe the metabolism of histamine in normal and tumor tissue and explain how tumor growth can be markedly reduced by treatment with a specific inhibitor of HDC, monofluoromethylhistidine, indicating that newly synthesized histamine plays an important role in the tumor development process. Cimetidine, a histamine H 2 receptor antagonist also inhibits tumor development whereas an H 1 receptor antagonist, dexchlorpheniramine favors tumor growth. Newly synthesized histamine appears to play a role in the basic mechanism of cell proliferation in tumoral cells. It may also suppress the host immune system by activation of histamine H 2 receptors on suppressor lymphocytes.
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