Abstract
The purpose of research is to designate the significance of histamine and symbiotic microbiota in the development of allergopathology in the first months of baby’s life. As a result of the study of 80 «mother-child» pairs with a burdened genetic history of allergopathology, it has been found that the intensity of histamine production by intestinal strains in women with intestinal microbiota disorders was significantly higher than that in women without it (2 = 4,6; p = 0,032). It has been revealed that the intensity of the histamine release depends on the severity of intestinal symbiotic microbiota disorders. The correlation between the severity of the gut microbiota disorders and the intensity of histamine release of intestinal strains of mothers with these indicators of their newborns (rs = 0,761; p < 0,05) has been revealed. The degree of severity of intestinal symbiotic microbiota disorders and the intensity of histamine release the baby’s risk of allergic disease development significantly affect the frequency of gastrointestinal and skin manifestations of allergies (2 > 3,8; p = 0,05).
Highlights
The purpose of research is to designate the significance of histamine and symbiotic microbiota in the development of allergopathology in the first months of baby’s life
As a result of the study of 80 «mother-child» pairs with a burdened genetic history of allergopathology, it has been found that the intensity of histamine production by intestinal strains in women with intestinal microbiota disorders was significantly higher than that in women without it ( 2 = 4,6; p = 0,032)
It has been revealed that the intensity of the histamine release depends on the severity of intestinal symbiotic microbiota disorders
Summary
Установлено, что степень выраженности микроэкологических нарушений кишечника и интенсивность гистаминообразования у младенцев «группы риска» достоверно влияют на частоту развития гастроинтестинальных и кожных проявлений аллергии ( 2 > 3,8; р = 0,05). Роль гистамина и симбиотической микробиоты в реализации риска аллергопатологии в первые месяцы жизни. Роль гистамина и симбиотической микробиоты в реализации риска аллергопатологии в первые месяцы жизни образование гистидина (аминокислотного компонента большого числа продуктов) в гистамин, но при нарушениях в ее составе реакция декарбоксилирования может протекать и в кишечнике, приводя к образованию и всасыванию больших количеств гистамина. Цель исследования — оценить участие гистамина и симбиотической микробиоты в реализации риска аллергопатологии в первые месяцы жизни у детей «группы риска»
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