Abstract
Psychostimulants, such as methamphetamine (METH), induce psychological dependence and we recently suggested that hippocampal α 2A-adrenergic receptor (α 2A-AR) is involved in METH-induced modulation of central nervous systems. The present study shows that pretreatment with yohimbine dose-dependently decreased the ambulatory hyperactivities induced by METH (2 mg/kg) in mice. Moreover, specific knock-down of the hippocampal α 2A-AR with infusion of anti-sense oligo DNA of α 2A-AR significantly suppressed ambulatory activity induced by METH administration. Infusion of sense oligo DNA of α 2A-AR into mouse hippocampus exerted no effects on the ambulatory activity. These observations strongly suggest the involvement of hippocampal α 2A-AR in the regulation of ambulatory activity induced by METH administration.
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