Role of high sensitive C-reactive protein as a marker in assessing severity of asthma

Abstract

Increased serum high sensitive C-reactive protein (hs-CRP) in asthma and its association with disease severity has been investigated in many studies. This study aimed to determine serum hs-CRP status in asthma versus healthy controls and to examine its ability in predicting asthma control. This is a comparative-descriptive and observational study was carried out in the TB & Respiratory Medicine, N.C Medical College and Hospital over a period of 6 months. Total 70 patients (both old and newly diagnosed cases) were selected for the study for case group patients were on maintenance treatment including inhaled corticosteroids and bronchodilators according to the guideline treatment of asthma. In our present study, a total of 70 patients were included out of which 38 (57.4%) were males. In our study, most of the patients were 51-70 years i.e., 38 out of 70 (54.2%), followed by 31-50. The mean hs CRP of Case group patients are 4.31±1.46 and in control group patients 0.83±0.07. Pulmonary function test using Spirometer was s done in all the patients (case and control). The FEV1 values are compared against hsCRP values. Statistical significance is assessed using Spearman’s correlation. Case group patients showing highly significant negative correlation of hsCRP with FEV1.