Abstract
As a nonhistone chromosomal protein,high mobility group B1 ( HMGB1 ) is involed in a va-riety of biological processes, including transcription, DNA repair, V (D) J recombination, differentiation, develop-ment,and extracellular signaling. Increased expression of HMGB1 is associated with the proliferation, invasion and metastasis of many tumor types. Furthermore, HMGB1 overexpression inhibits apoptosis of cancer cells and tumor suppressor genes,resuhing in the genesis and development of tumor. HMGB1 plays roles in activation of plasminogen and matrix metalloproteases,reorganization of cytoskeleton. HMGB1 can also be involved in DNA damage repair,preventing cell carcinogenesis. HMGB1 can increase the sensitivity of breast cancer cells to γ-ray radiation. Key words: HMGB1 protein; Neoplasm metastasis; Radiobiology
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