Abstract
The paper analyzes the literature on glomerulonephritis and nephrotic syndrome, which are associated with herpesvirus types 1/2, 4, 5, and 7 infection, in children. The main pathogenetic mechanisms and clinical and morphological characteristics of herpesvirusassociated glomerulonephritis and nephrotic syndrome are considered. These diseases are shown to be frequently accompanied by immune disorders involving innate and adaptive immunity and interferonogenesis. Virus-associated glomerulonephritis and nephrotic syndrome are characterized by transient resistance to therapy with prednisone and cytotoxic agents and by a serious prediction. Clinical and immunological studies have proven that immunostimulatory (interferon-α2) and antiviral (acyclovir, ganciclovir) therapies result in restoration of prednisolone sensitivity and in complete or partial remission of virus-associated glomerulonephritis and idiopathic nephrotic syndrome in children. It is recommended that cytotoxic therapy should be prescribed if there is no activation of herpesvirus (types 1/2, 4, 5) infection, which has been achieved by antiviral and immunostimulatory therapies.
Highlights
The paper analyzes the literature on glomerulonephritis and nephrotic syndrome, which are associated with herpesvirus types 1/2, 4, 5, and 7 infection, in children
Virus-associated glomerulonephritis and nephrotic syndrome are characterized by transient resistance to therapy with prednisone and cytotoxic agents and by a serious prediction
Clinical and immunological studies have proven that immunostimulatory and antiviral therapies result in restoration of prednisolone sensitivity and in complete or partial remission of virus-associated glomerulonephritis and idiopathic nephrotic syndrome in children
Summary
The paper analyzes the literature on glomerulonephritis and nephrotic syndrome, which are associated with herpesvirus types 1/2, 4, 5, and 7 infection, in children. Гломерулонефрит и нефротический синдром, ассоциированные с герпесвирусной инфекцией у детей Вирусассоциированными считают гломерулонефрит и нефротический синдром, при которых установлены этиологическая и/или патогенетическая роль вирусной инфекции [1,2,3,4]. Исследования демонстрируют высокую частоту выявления персистирующей герпесвирусной инфекции у детей с различной патологией почек, в том числе при гломерулонефрите и нефротическом синдроме [2, 3, 6, 7, 9, 10].
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