Abstract
This study was designed to investigate the effects of hepatic denervation (HD) on NaCl balance and arterial blood pressure in conscious Wistar-Kyoto rats maintained on normal or high-NaCl food. When rats were fed normal NaCl food (0.45% NaCl), HD had no significant effect on NaCl balance and arterial pressure. However, when rats were fed high-NaCl food (8% NaCl for 10 days), NaCl balance became more positive in HD rats than in sham rats. Furthermore, mean arterial pressure in HD rats (120 ± 2 mmHg) was higher than that in sham rats (108 ± 3 mmHg). These results indicate that the hepatic nerves play a significant role in the long-term control of NaCl balance and arterial pressure during high-NaCl food intake.
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