Abstract
Role of heat labile and heat stable enterotoxins in the induction of early immune responses in piglets after infection with enterotoxigenic Escherichia coli
Highlights
Enterotoxigenic Escherichia coli (ETEC) strains that produce heat-stable (ST) and/or heat-labile (LT) enterotoxins are cause of post-weaning diarrhea in piglets
Several isogenic mutant strains of an O149:F4ac+, LT+ STa+ STb+ ETEC strain were constructed that lack the expression of LT in combination with one or both types of ST enterotoxins (STa and/or STb)
The small intestinal segment perfusion (SISP) technique and microarray analysis were used to study host early immune responses induced by these mutant strains 4h after infection in comparison to the wild type strain and a PBS control
Summary
Enterotoxigenic Escherichia coli (ETEC) strains that produce heat-stable (ST) and/or heat-labile (LT) enterotoxins are cause of post-weaning diarrhea in piglets. Michaela Loosa,1, Marisa Geensb,1, Stijn Schauvliegec, Frank Gasthuysc, Jan van der Meulend, Bruno Goddeerisa,b, Theo Niewoldb and Eric Coxa
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